Glycine
The simplest amino acid with the deepest research.
Free-form glycine for sleep quality, collagen synthesis, and cognitive support. The most studied amino acid for non-sedative sleep improvement.
Formulations shown reflect target specifications and are subject to change during development. Final products may vary in dosage, capsule count, or ingredient sourcing.
Supplement Facts
Other Ingredients
Vegetarian capsule (hypromellose).
Usage & Dosage
Serving Size: 3 capsules
Take 3 capsules approximately 30–60 minutes before bedtime, or as directed by a healthcare professional.
If you are pregnant, nursing, taking medication, or have a medical condition, consult your healthcare provider before use. Keep out of reach of children.
Why this form.
Glycine is the smallest and simplest amino acid, but its role in human physiology is anything but simple. It is a key building block of collagen (the most abundant protein in the body), a precursor to glutathione (the body’s master antioxidant), and a co-agonist at NMDA receptors in the brain. Research from the Ajinomoto Group in Japan demonstrated that 3g of glycine taken before bed significantly improved subjective sleep quality and next-day cognitive performance — without the sedative hangover of melatonin or pharmaceutical sleep aids.
As a free-form amino acid, glycine requires no digestion or chelation — it absorbs rapidly through amino acid transporters in the small intestine. Peak plasma levels are typically reached within 30–60 minutes of oral ingestion. The 3g dose used in clinical sleep studies is well above the amount obtainable from diet alone, supporting the case for targeted supplementation.
Key Benefits
Research highlights.
Improved Sleep Quality
3g of glycine before bed significantly improved subjective sleep quality, sleep efficacy, and reduced daytime sleepiness in individuals with sleep complaints.
Inagawa et al., 2006 — Sleep and Biological RhythmsNext-Day Cognitive Performance
Glycine supplementation before sleep improved next-day cognitive performance, including memory recognition and psychomotor vigilance, in sleep-restricted subjects.
Bannai et al., 2012 — Frontiers in NeurologyThermoregulatory Mechanism
Glycine lowers core body temperature by increasing peripheral blood flow, mimicking the natural thermoregulatory process that initiates sleep onset.
Kawai et al., 2015 — Neuropsychopharmacology
